He used his unstoppable feet to help the team win the championship easily and look back on his career.

In the 2003 NBA Draft, Zazapachulia, a inside player from Georgia, was selected by the Orlando Magic with the 42nd overall pick in the second round. Before the training camp in the new season, the Orlando Magic announced that they had officially signed Zazapachulia with a 2-year and 98-year rookie contract. Since then, Zazapachulia has started his NBA career.

In the 2003-2004 season, Zazapachulia, who had just entered the league, was not valued by the Magic's coaching staff. He could only play as Andrew Deklek's second substitute. In that season, Zazapachulia played 59 regular season games for the Magic, including 2 starts, and averaged 11.2 minutes per game to contribute 3.3 points and 2.9 rebounds. The Magic ranked last in the league with 21 wins and 61 losses. Zazapachulia during the Magic's period 23 June 2004, the Charlotte Bobcats selected Zazapachulia from the Orlando Magic in their expansion draft as the new NBA. The Charlotte Bobcats then traded Zazapachulia to the Milwaukee Bucks for the 2004 No. 45 pick Bernard Robinson.

In the 2004-2005 season, Zazapachulia played as a substitute for Dangazuric, and his average playing time was increased compared to last season. In that season, Zazapachulia played 74 regular season games for the Bucks, including 4 starts, and averaged 6.2 points and 5.1 rebounds per game. The Bucks ranked third from the bottom in the Eastern Conference with 30 wins and 52 losses. Zazapachulia during the Bucks' period On August 4, 2005, the Atlanta Hawks announced that they would sign Zazapachulia with a four-year, $16 million contract.

In the 2005-2006 season, Zazapachulia played as the team's starting center. His average playing time increased significantly compared to last season. He ranked first in the team with average rebounds and third in the team's average score. In that season, Zazapachulia played 78 regular season games for the Hawks, all starting, and averaged 31.4 minutes per game to contribute 11.7 points, 7.9 rebounds, 1.7 assists and 1.1 steals. The Hawks ranked second from the bottom in the East with 26 wins and 56 losses.

In the 2006-2007 season, Zazapachulia still played as the team's starting center. He ranked first in the team with average rebounds and his average score average reached the highest in his career. In the late season, Zazapachulia suffered from injuries and gradually became the team's substitute player. In that season, Zazapachulia played 62 regular season games for the Hawks, including 47 starts, and averaged 28.1 minutes per game to contribute 12.2 points, 6.9 rebounds, 1.5 assists and 1.1 steals. The Hawks ranked third from the bottom in the East with 30 wins and 52 losses. In the 2007-2008 season, Zazapachulia, as the team's substitute center, Zazapachulia became the team's substitute center due to the Tanhua show El Horford joining the team. His average playing time was significantly lower than last season. In that season, Zazapachulia played 62 regular season games for the Hawks, including 5 starts, and averaged 5.2 points and 4 rebounds per game. The Hawks ranked eighth in the Eastern Conference with 37 wins and 45 losses, losing to the Boston Celtics 3-4 in the first round.

In the 2008-2009 season, Zazapachulia still played as Al Horford's substitute, and only started in the games that Al Horford missed. In that season, Zazapachulia played 77 regular season games for the Hawks, including 26 starts, averaging 19.1 minutes per game, and averaged 6.2 points and 5.7 rebounds. The Hawks ranked fourth in the Eastern Conference with 47 wins and 35 losses. They defeated the Miami Heat 4-3 in the first round. They were swept out by the Cleveland Cavaliers 0-4 in the Eastern Conference semi-finals and missed the Eastern Conference Finals.

On July 13, 2009, the Atlanta Hawks announced the renewal of Zazapachulia with a four-year, $19 million contract. In the 2009-2010 season, Zazapachulia played as Al Horford's substitute. His average playing time and data declined further. In that season, Zazapachulia played 78 regular season games for the Hawks, one of which started and averaged 4.3 points and 3.8 rebounds per game. The Hawks ranked third in the Eastern Conference with 53 wins and 29 losses. They defeated the Milwaukee Bucks 4-3 in the first round. The Eastern Conference semi-finals were swept out by the Orlando Magic 0-4 and missed the Eastern Conference finals.

In the 2010-2011 season, Zazapachulia's average playing time has not changed significantly compared to last season. In that season, Zazapachulia played 79 regular season games for the Hawks, including 7 starts, and averaged 4.4 points and 4.2 rebounds per game. The Hawks ranked fifth in the Eastern Conference with 44 wins and 38 losses. They defeated the Orlando Magic 4-2 in the first round, and lost to the Chicago Bulls 2-4 in the Eastern Conference semi-finals and missed the Eastern Conference finals.

In the 2011-2012 season, due to injury at the beginning of the season, Zazapachulia got the opportunity to start and play. His average playing time was significantly higher than last season. In that season, Zazapachulia played 58 regular season games for the Hawks, including 44 starts, and averaged 7.8 points, 7.9 rebounds and 1.4 assists per game. The Hawks ranked fifth in the Eastern Conference with 40 wins and 26 losses, losing to the Boston Celtics 2-4 in the first round. In the 2012-2013 season, Zazapachulia played as the team's substitute center. In that season, Zazapachulia played 52 regular season games for the Hawks, including 15 starts, and averaged 5.9 points, 6.4 rebounds and 1.5 assists per game. The Hawks ranked sixth in the Eastern Conference with 44 wins and 38 losses, and lost to the Indiana Pacers 2-4 in the first round.

On July 7, 2013, the Milwaukee Bucks announced the signing of Zazapachulia for a three-year, $15.6 million contract.

In the 2013-2014 season, Zazapachulia played as the team's starting center, and his average assists reached a career-highest average. In that season, Zazapachulia played 53 regular season games for the Bucks, including 43 starts, and averaged 7.7 points, 6.3 rebounds and 2.6 assists per 25 minutes. The Bucks ranked last in the league with 15 wins and 67 losses. In the 2014-2015 season, Zazapachulia still played as the team's starting center. In the mid-season, in order to strengthen Giannis Antetokounmpo's lethality in the inside, the Bucks coaching staff promoted Eisen Iliasova, who had stronger shooting ability, to start the team. This season, Zazapachulia played 73 regular season games for the Bucks, including 45 starts, and averaged 23.7 minutes per game to contribute 8.3 points, 6.8 rebounds, 2.4 assists and 1.1 steals. The Bucks ranked sixth in the Eastern Conference with 41 wins and 41 losses, and lost to the Chicago Bulls 2-4 in the first round.

On March 21, 2015, the Bucks challenged the Nets away. Zazapachulia started for 40 minutes in the whole game, made 9 of 16 shots, and made 4 free throws and contributed 22 points, 21 rebounds, 7 assists and 1 steal. Among them, 21 rebounds were Zazapachulia's highest single-game rebounds in his career, 18 of the 21 basketballs were frontcourt rebounds, and 18 frontcourt rebounds tied the highest single-game rebound record since 1985.

On July 10, 2015, the Milwaukee Bucks traded Zazapachulia to the Dallas Mavericks and received a future second-round pick.

In the 2015-2016 season, Zazapachulia played as the team's starting center, and his average rebounding average reached a career-highest career. In that season, Zazapachulia played 76 regular season games for the Mavericks, including 69 starts, and averaged 8.5 points, 9.5 rebounds and 1.7 assists per game. The Mavericks ranked sixth in the Western Conference with 42 wins and 40 losses, losing 1-4 to the Oklahoma City Thunder in the first round. Zazapachulia during the Mavericks' time on July 17, 2016, the Golden State Warriors announced that they would sign Zazapachulia with a one-year, $2.89 million contract.

Although Zazapachulia played as the team's starting center, his average playing time was only sixth in the team. In that season, Zazapachulia played 70 regular season games for the Warriors, all starting games, and averaged 6.1 points, 5.9 rebounds and 1.9 assists per game. The Warriors ranked first in the league with 67 wins and 15 losses. They swept the Portland Trail Blazers 4-0 in the first round, swept the Utah Jazz 4-0 in the Western Conference Semi-Finals, swept the San Antonio Spurs 4-0 in the Western Conference Finals, and swept the San Antonio Spurs 4-0 in the Western Conference Finals. The Warriors defeated the Cleveland Cavaliers 4-1 in the Finals to win the fifth championship in team history. Zazapachulia won the first championship trophy in his career.

On May 15, 2017, in the first game of the NBA playoffs, the Warriors faced the Spurs at home. After the game started, the Spurs quickly took the lead with a blast. The Spurs once led by 23 points in the third quarter. However, due to Zazapachulia's footsteps, the Spurs leader Kawhi Leonard, the latter was injured and reimbursed the season. The Warriors took the opportunity to play attacking waves continuously, and finally defeated the Spurs 113-111, and then swept the Spurs 4-0 to enter the finals. Zazapachulia during the Warriors' Warriors' era On July 25, 2017, the Golden State Warriors announced that they would renew Zazapachulia with a one-year, $3.46 million contract.

In the 2017-2018 season, Zazapachulia still played as the team's starting center. Javier McGee was promoted to the team's starter in the late season. Zazapachulia was gradually abandoned by the Warriors' coaching staff. In that season, Zazapachulia represented the Warriors in 69 regular season games, including 57 starts, averaging 14.1 minutes per game, and averaged 5.4 points, 4.7 rebounds and 1.6 assists. The Warriors ranked second in the Western Conference with 58 wins and 24 losses. They defeated the San Antonio Spurs 4-1 in the first round, defeated the New Orleans Pelicans 4-1 in the Western Conference semi-finals, defeated the Houston Rockets 4-3 in the Western Conference Finals, and won the sixth championship in the team's history. Zazapachulia won the second championship trophy in his career.

On July 9, 2018, the Detroit Pistons announced that they would sign Zazapachulia with a one-year, $2.39 million contract. In the 2018-2019 season, Zazapachulia played as Andre Drummond's substitute. In the season, Zazapachulia played 68 regular season games for the Pistons, including three starters, averaging 12.9 minutes per game, and averaged 3.9 points, 3.9 rebounds and 1.3 assists. The Pistons ranked eighth in the Eastern Conference with 41 wins and 41 losses. They were swept out by the Milwaukee Bucks 0-4 in the first round.

On September 7, 2019, Zazapachulia officially announced her retirement through social media, ending her career as a player. Since then, this inside player with mid- and long-distance shooting has completely left the NBA arena.